Endoscopic resection of a large colonic leiomyosarcoma.

Leiomyosarcoma of the colon is a rare tumor (330 reported cases [1]) which can mimic an adenocarcinoma [2]. Contrastenhanced computed tomography (CT) is the imaging method of choice in the diagnostic work-up, though magnetic resonance imaging may be useful. Endoscopy and endoscopic ultrasonography (EUS) are also useful for further characterizing the lesion, and are helpful in distinguishing a benign lesion from a malignant one [3]. Positron emission tomography can be used to monitor the response to therapy or detect local recurrence [2]. The management of leiomyosarcomas involving the gastrointestinal tract depends on the confidence in the preoperative diagnosis, and the treatment of choice is radical surgical excision [4]. No data are available on endoscopic treatment in patients who cannot undergo surgery. A 64-year-old man affected with hepatitis C virus-related decompensated cirrhosis was admitted to our hospital because of rectal bleeding. At colonoscopy a large sigmoid polyp (diameter 2.5cm) was found (●" Fig.1a). At EUS with a 20-mHz miniprobe the polyp was seen as rising from the second and third layers (●" Fig.1b). At histopathology the diagnosis was true leiomyosarcoma. CT scan was negative for metastatic lesions. Taking into account the severe liver disease, and in agreement with the surgeon, an endoscopic mucosectomy was performed after injection with saline, epinephrine, and dilute methylene blue into the base, obtaining a complete lift. The polyp was resected en bloc with a snare, using coagulation current followed by Endo Cut current. At the end, clips were placed at the mucosectomy site to prevent delayed bleeding (●" Fig.1c). The histopathology of the resected specimen confirmed the diagnosis (●" Fig.1d). At 6-month distal endoscopy there was no local recurrence (●" Fig.1e), and PET scan was negative. Although surgery is the treatment of choice in operable patients affected with leiomyosarcoma, this report shows that in selected inoperable patients with no metastatic disease, endoscopic excision of leiomyosarcoma can be an effective and safe nonsurgical approach.